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| Clinical and Experimental Research of Compound Huangqi Danshen Granule on Treating Angina Pectoris |
| Hits 1558 Download times 1757 Received:April 05, 2002 |
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| DOI
10.11656/j.issn.1672-1519.2002.04.06 |
| Key Words
coronary heart disease;angina pectoris;Compound Huangqi Danshen Granule (CHDG) |
| Author Name | Affiliation | | Zhang Boli | Tianjin University of TCM, Tianjin 300193, China | | Su Ya | 天津药物研究院 天津300193 | | Gao Xiumei | Tianjin University of TCM, Tianjin 300193, China | | 董志立 | 天津医药总公司 天津300150 | | 徐宗佩 | Tianjin University of TCM, Tianjin 300193, China | | 王晓晖 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| Objective: To study the clinical and pharmacodynamic influence of Compound Huangqi Danshen Granule (CHDG) on angina pectoris. Methods: 246 cases were divided into two groups: control group (n=82) and treatment group (n=164) randomly taking Compound Danshen Tablet (CDT) and CHDG separately. Each course had 4 weeks. The improvement of the ECG and symptoms and the reducing need of the tablets served as evaluated indices. In experiments, 27 male wistar rats were randomly divided into three groups: control group, CHDG at 200 mg/kg group and CHDG at 400mg/kg group. Medicines were administrated an hour coronary artery ligation. The elevation of ST-segment and the area of myocardial infarction were observed. Results: The clinical effective rate, incidence and duration of angina and ECG change were superior in treatment group to those in control group. There was a significant difference (P<0.05, P<0.01). The mV value of ST-segment at different time points in treatment group were lower than in control group, and the area of myocardial infarction was less too (P<0.05, P<0.01).CHDG at 400 mg/kg group had a more obvious effect than theother treatment group. Conclusion: CHDG has a protective effect against injury of myocardial muscles due to myocardial infarction and notably improves the symptoms of angina pectoris, resulted from qi deficiency and blood stasis. |
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