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| Inhibitory Effect of Jiawei Qingyi Decoction on Bacterial Translocation of Rats with Acute Necrotizing Pancreatitis |
| Hits 1504 Download times 1679 Received:December 15, 2001 |
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| DOI
10.11656/j.issn.1672-1519.2002.05.31 |
| Key Words
acute necrotizing pancreatitis;Jiawei Qingyi Decoction;bacterial translocation;rat |
| Author Name | Affiliation | | Liu Changbao | The Second Affiliated Hospital to Wenzhou Medical College, Wenazhou 325027, China | | Cui Naiqiang | 天津市南开医院, 天津, 300100 | | Wang Zhanguo | 东北煤炭勘探一局卫生院, 吉林, 134000 |
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| Abstract
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| Objective: To observe the effect of the traditional Chinese medicine Jiawei Qingyi Decoction (JQD) on bacterial translocation in rats with acute necrotizing pancreatitis (ANP). Methods: 56 Wistar rats were randomly divided into four groups, each containing 14 rats: control group, JQD group, imipenem group, ciprofloxacin group. JQD or antibiotics were given 2 hours before and 6, 8 hours after ANP. Animals were sacrificed 12, 24 hours after onset of ANP and pancreas, spleen, mesenteric lymph nodes, liver, lung samples were collected for bacterial culture. The levels of lipopolysaccharide (LPS) and amylase in blood were determined, and the histology of terminal cecum was examined.Results: The results indicated that the time of bacterial translocation in JQD group was delayed, the number of bacteria in each organs was significantly lower than those in other groups and the levels of LPS and amylase was also lower than other groups. Conclusion: JQD can alleviate the damage of intestinal mucosa and may be a promising approach in the prophylaxis and treatment of infection in ANP. |
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