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| Clinical effect of Shengmai Injection on blood digoxin concentration and pharmacokinetics in patients with heart failure |
| Hits 1551 Download times 1691 Received:October 14, 2002 |
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| DOI
10.11656/j.issn.1672-1519.2003.02.08 |
| Key Words
Shengmai Injection;Digoxin;blood concentration;pharmacokinetics;congestive heart failure |
| Author Name | Affiliation | | Mao Jing-yuan | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | Wang Heng-he | 天津中医学院, 天津, 300193 | | Wang Qiang | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 常延平 | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 张其梅 | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 郑颖 | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 吴慧轩 | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 张宇 | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 李红 | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 张运 | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| [Objective] To study the clinical effect of Shengmai Injection on blood digoxin concentration and pharmacoki-netics in patients with heart failure. [Method] Forty cases with congestive heart failure were randomly divided into 4 groups:group 1(Digoxin),group 2,3,4(Digoxin and Shenmai Injection with 20mL,40mL,60mL respectively).Each group had 10cases.The blood concentration of Digoxin in all groups was detected with radioimmunoassay(RIA)and the pharmacokinetics parameter,were calculated with 3P97 pharmacokinetics software. [Result] There was an obvious differ-ence between group1and group 2 in pharmacokinetics parameters(P<0.05),such as the blood digoxin concentration,T(1/2),Vd,CL,and so on.But there was no difference between group1and group 3,group1and group 4 (P>0.05). [Conclusion] Shengmai Injection with low dosage can decrease the blood digoxin concentration and shorten T(1/2)in the patients with congestive heart failure. |
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