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| Influence of Chinese decoction Gengnianle on monoamine neurotransmitter in climacteric rats |
| Hits 1447 Download times 2084 Received:August 04, 2002 |
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| DOI
10.11656/j.issn.1672-1519.2003.02.14 |
| Key Words
Gengnianle;climacteric syndrome;tonifying the kidney and smoothing the liver;regulating and tonifying the Chong and Ren Channels;monoamine neurotransmitter |
| Author Name | Affiliation | | WANG Bin | The Fourth Military Medical University, Xian 710032, China | | LIU Hong-yan | 天津中医学院, 天津, 300193 | | WANG Hong | 天津中医学院, 天津, 300193 | | 吴高媛 | 天津中医学院, 天津, 300193 |
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| Abstract
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| [Objective] To study the influence on monoamine neurotransmitter in climacteric rats treated by Chinese decoc-tion Gengnianle with the effect of tonifying the kidney,smooth the liver and regulating and tonifying the Chong and Ren Channels. [Method] Twenty-five rats(age:11～15months)were randomly divided into model group and treatment group. Eight rats(age:3months)consisted of the young rat control group.The decoction was given to the treatment group while normal saline to the other two groups.Monoamine neurotransmitter at hypothalamus including NE,DA,5-HT,5-HIAA were detected by HPLT-electrochemical method. [Result] Gengnianle could decrease 5-HT and 5-HIAA(P<0.01,P<0.05),increase NE(P<0.05)and make the ratio of 5-HT/NE near to that of young rat control group(P<0.01). [Conclusion] Chinese decoction Gengnianle can improve the function of hypothalamus through regulating the level of monoamine neurotransmitter. |
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