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| Influence of Huoxue Ruanjian Principle on pathology and cytokine of renal tissue and cyotodine in rabbits with membranous nephropathy |
| Hits 1539 Download times 1933 Received:January 10, 2003 |
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| DOI
10.11656/j.issn.1672-1519.2003.02.32 |
| Key Words
Huoxue Ruanjian Principle;membranous nephritis;cytokine;pathology of renal tissue |
| Author Name | Affiliation | | YANG Hong-tao | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | XING Hai-tao | 天津中医学院, 天津, 300193 | | ZHAO Jing-li | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 林燕 | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 黄文政 | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the influence of Huoxue Ruanjian Principle on renal histomorphology and cytokine in rabbits with membranous nephropathy. [Method] Forty male white rabbits were divided into 4 groups:control group,model group,Leigongteng group and Huoxue Ruanjian group.The model was made according to Borde Mehtod.The drug was given to each corresponding group with normal saline in the control and model group. [Result] Ruanjian Huoxue Decoction could decrease the formation of immunocomplex in situ,the thickness of the basement membrane and prevent the formation of capillary microthrombus in crescent and glome rulus.It could also inhibit the activity of TNF-α,decrease the content of IL-1,IL-6 and PAF in plasma. [Conclusion] Huoxue Ruanjian Principle can ameliorate the production and development of glomerular necrosis by eliminating the pathological injury to glomerulus of rabbit with membranous nephritis. |
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