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| Mechanism research of Siwu Decoction and every combination of two herbs in it on mice with blood deficiency syndrome induced by γ-ray |
| Hits 1373 Download times 2247 Received:April 14, 2003 |
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| DOI
10.11656/j.issn.1672-1519.2003.04.31 |
| Key Words
Siwu Decoction;blood deficiency syndrom;CD34+ cell;NFS60 cell |
| Author Name | Affiliation | | ZHU Li-jun | Institute of Radiation Medicine of Academy of Military Medical Sciences, Beijing 100850, China | | LU Xiao-qin | Institute of Radiation Medicine of Academy of Military Medical Sciences, Beijing 100850, China | | TAN Hong-ling | Institute of Radiation Medicine of Academy of Military Medical Sciences, Beijing 100850, China | | 肖成荣 | Institute of Radiation Medicine of Academy of Military Medical Sciences, Beijing 100850, China | | 高月 | Institute of Radiation Medicine of Academy of Military Medical Sciences, Beijing 100850, China |
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| Abstract
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| [Objective] To study the mechanism of Siwu Decoction and every combination of two herbs in it on mice with blood deficiency syndrome. [Methods] The blood deficiency model was by systemic irradiation of 60Coγ-ray on mice. Peripheral hemogram, CD34+ cell, cell cycle, proliferation of NFS60 cell and hemopioetic cell were observed. [Result] 1) All indexes of Siwu Decoction was superior to that of other combination. 2) The combination related with Danggui could improve CFU-E, CFU-Mix and CFU-GM and enhance WBC. The combination related with Dihuang could promote the proliferation of CFU-E. The combination related with Baishao could improve the proliferation of NF60 cell markedly. The combination related with Chuanxiong could promote CD34 antigen expression and accelerate cell transformation from G0/1 phase to S phase. The effect of the last combination was associated with ligustrazine. [Conclusion] The whole decoction, Siwu Decoction is superior to other combination. The effect target and the effect strength of each combination is different. |
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