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| Age-related changes in telomere of brain cell in SAMP10 |
| Hits 1874 Download times 1435 Received:May 19, 2003 |
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| DOI
10.11656/j.issn.1672-1519.2003.05.13 |
| Key Words
SAMP10 mouse;telomere of brain cell;aged-related change |
| Author Name | Affiliation | | WANG Shu | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | DONG Cheng-chao | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | LU Bin | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| [Objective] To study the age-related changes in telomere of brain cell of mice with brain aging animal.[Methods] SAMP10 was taken as as brain aging animal model. The Southern hybridization was used to measure the changes in telmere of brain cell in different month-age between SAMR1 and SAMP10.[Results] The length of telomere in SAM was 17～25 kb and there was a decreasing trend in brain cell telomere of SAMP 10 while aging.[Conclusion] The contraction of cell telomere has a marked correlation to senile. |
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