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| Experimental research about the effect of Feiyi Wan on angiogenesis and metastasis in patients with lung cancer transfer |
| Hits 1589 Download times 2340 Received:July 10, 2003 |
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| DOI
10.11656/j.issn.1672-1519.2003.05.30 |
| Key Words
tumor;angiogenesis;metastasis;Feiyi Wan |
| Author Name | Affiliation | | TIAN Fei | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | JIA Ying-jie | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | CHEN Jun | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 贾彦焘 | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 孙一予 | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| [Objective] To confirm that FeiYi Wan is able to suppress the generation of blood vessel and cancer metastasis.[Methods] 1) Adopting the model of CAM,put the carrier containing abstracted liquid of Feiyi Wan into CAM cultivated for 7 d. After 48 h, observe the condition of angiogenesis and compare it with group using hydrocortisone. 2) Adopt the model of rabbit cornea transfplanted tumor observe the effect of Feiyi Wan in angiogeneisis. 3) Adopt T739 model of subcutaneous inoculated tumor from LA795 lung adenocarcino in mice to observe the effect of FeiyiWan in suppressing the generation of blood vessel and the metastasis of lung cancer.[Results] Feiyi Wan can reduce obviously, even dissolve, the generation of blood vessolve in CAM and rabbit cornea transferplanted adenocarcino. Feiyi Wan can suppress the growth of the tumor. The ratio of suppressing tumor is 49.6%. It can low the density of blood vessel, the ratio to suppress the transfer of lung cancer is 60%.[Conclusion] Feiyi Wan can suppress the generation of blood vessel from in CAM and rabbit cornea transplanted tumor and transplanted adenocarcino tumor.At the same time, Feiyi Wan also can resist the metastasis of tumor. This research show that Feiyi Wan can suppress the growth and of tumor based on reduce the generation of blood. |
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