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| Influence of Chinese medicine Tiaogan Daozhuo Decoctionon on PDGF-A and PDGFR-αexpression in rabbits with AS |
| Hits 1600 Download times 1404 Received:March 13, 2003 |
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| DOI
10.11656/j.issn.1672-1519.2003.05.33 |
| Key Words
PDGF;receptor;immunohistochemistry |
| Author Name | Affiliation | | ZHANG Hong_xia | 天津中医学院第二附属医院, 天津, 300150 | | LI Guang_bin | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | JIANG Xi_juan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 范英昌 | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| [Objective] To investigate the effect of Chinese medicine Tiaogan Daozhuo Decoction on PDGF-A and PDGFR-α expression in rabbits with AS.[Methods] The rabbits were fed with cholesterol-rich diet and underwent different management in each group simultaneously.The aorta was obtained for immunohistochemical examination at the end of experiment.[Results] In the model group, the aorta showed a heavily pathological changes of AS. And the positive expression of PDGF-A and PDGFR-α increased markedly. Tiaogan Daozhuo Decoction could inhibit the expression effectively.[Conclusion] Tiaogan Daozhuo Decoction can prevent the formation and progress of AS by inhibiting the increased expression of PDGF-A and PDGFR-αinduced by cholesterol-rich diet. |
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