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| Effects of Si-Wu-Tang and its extracts on medullary hematopoiesis in mice of blood deficency induced by 60Coγ irradiation |
| Hits 2237 Download times 2466 Received:March 10, 2003 |
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| DOI
10.11656/j.issn.1672-1519.2003.06.23 |
| Key Words
Si_Wu_Tang;blood deficiency;hematopoiesis;gene chip |
| Author Name | Affiliation | | GAO Yue | Institute of Radiation Medicine, Beijing 100850, China | | MA Zeng-chun | Institute of Radiation Medicine, Beijing 100850, China | | TAN Hong-ling | Institute of Radiation Medicine, Beijing 100850, China | | 佟丽 | Institute of Radiation Medicine, Beijing 100850, China | | 戴维群 | 吉林大学中日联谊医院, 长春, 130023 | | 肖成荣 | Institute of Radiation Medicine, Beijing 100850, China | | 王升启 | Institute of Radiation Medicine, Beijing 100850, China |
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| Abstract
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| [Objective] To study the mechanism and active constituents of Si-Wu-Tang on the blood deficiency induced by using 60Coγ irradiation.[Methods] Blood deficient mice were established by using 60Coγ irradiation, the ability of colony-forming unit of bone marrow cells and the number of circulating blood cells have been observed, the molecule mechanism of Paeoniae on enriching blood was investigated by gene chip.[Results] Si-Wu-Tang and its butyalcohol and h2o extracts could increase the numbers of circulating white blood cells, Si-Wu-Tang and Paeoniae could increased the ability of colony-forming, GM-CSF, G-CSF, PDGF-α increased and MIP decreased in stromal cells treated by Paeoniae.[Conclusion] Paeoniae might be one of active constituents of Si-Wu-Tang on the blood deficiency, stimulated producing GM-CSF, G-CSF,PDGF-α in stromal cells mignt be the mechanism of SWT on the BD mice. |
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