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| Effect of Changan Capsule on immune mechanism in rats with ulcerative colitis |
| Hits 1270 Download times 1795 Received:August 27, 2003 |
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| DOI
10.11656/j.issn.1672-1519.2003.06.28 |
| Key Words
Changan capsule;IL_2;TNF_α;circulatory immunocomplex;ulcerative colitis |
| Author Name | Affiliation | | LIU Wan-li | Nanjin Hospital of Tradition Chinese Medicine, NanJin 210029, China | | SHEN Hong | 南京中医药大学附属医院, 南京, 210029 | | SHAN Zhao-wei | 南京中医药大学附属医院, 南京, 210029 | | 朱萱萱 | 南京中医药大学附属医院, 南京, 210029 | | 俞晶华 | Nanjin Hospital of Tradition Chinese Medicine, NanJin 210029, China |
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| Abstract
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| [Objective] To observe the effect of Changan capsule on immune mechanism in rats with ulcerative colitis,and to explore its mechanism of action.[Methods] Modle rats were established by the methods of immune and local stimulation, and the content of serum immunoglobulin G, immunoglobulin A, (IgG, IgA), circulatory immunocomplex(CIC), interleukin-2(IL-2), tumor necrosis factor-α(TNF-α) of each group were detected after the treatment.[Results] The content of serum IgG and CIC increased in experimental rats, the level of IL-2 and TNF-α remained abnormal. The above indexes all had obvious improvement after the treatment.[Conclusion] Changan capsule can inhibit the synthesis of IgG, clear CIC, inhibit the yields of TNF-α,and regulate the level of IL-2. |
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