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| Study on dissolution test method of Silybin Solid Dispersion Capsules |
| Hits 1951 Download times 1478 Received:October 20, 2003 |
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| DOI
10.11656/j.issn.1672-1519.2004.01.33 |
| Key Words
silybin;solid;dispersion;dissolution |
| Author Name | Affiliation | | REN Xiao-wen | Tianjin Institute of Medicine, Tianjin 300193, China | | XU Wei-ren | Tianjin Institute of Medicine, Tianjin 300193, China | | LIAN Xiao-yan | Tianjin Institute of Medicine, Tianjin 300193, China | | 马晋 | Tianjin Institute of Medicine, Tianjin 300193, China | | 李洪起 | Tianjin Institute of Medicine, Tianjin 300193, China |
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| Abstract
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| [Objective] To establish a method in determining the dissolution of silybin solid dispersion capsules. [Methods] According to the description in Chp.2000.VolⅡ.Appendix XC, the dissolution of silybin solid dispersion capsules was determined by UV-VIS spectrophotometer. [Results] The selected media for dissolution test is phosphate buffer solution with 0.5% Brij35 (pH7.8～8.0).The dissolution of capsules has good reproducibility. [Conclusion] The method is considered to be a accurate and reliable dissolution determination for silybin capsules. |
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