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| Influence of Jiuxin capsule on expression of adhesion molecule in injured endothelial cell |
| Hits 1627 Download times 1378 Received:October 18, 2003 |
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| DOI
10.11656/j.issn.1672-1519.2004.02.29 |
| Key Words
Jiuxin capsule;endothelial cell;adhesion molecule |
| Author Name | Affiliation | | ZHAO Gui-feng | Tianjin University of TCM, Tianjin 300193, China | | ZHANG Hong-xia | 天津中医学院第二附属医院, 天津, 300150 | | FAN Ying-chang | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the protective function of Jiuxin capsule on endothelial cell by inhibiting the expression of adhesion molecule in injured endothelial cell.[Methods] Injured endothelial cell model was established by hypoxia and giving low density lipoprotein(LDL). The effect of two kinds of different solutions:sterilized extract fluids of Chinese herbs and drug-carried serum were administered. The expression of adhesion molecule was determined by immunocytochemistry.[Results] Obviously increased expression of adhesion molecule was observed after injury of endothelial cell,Jiuxin capsule decreased its expression significantly.[Conclusion] Jiuxin capsule has a good protective action against endothelial cell injury.It can produce a delay in occurrence and development of coronary heart diseases by preventing endothelial cell injury induced by inflammatory mediators. |
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