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| Research on effect of Jiuxin Capsule on the ability of anti-oxidation injury in endothelial cell |
| Hits 1749 Download times 1885 Received:February 19, 2004 |
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| DOI
10.11656/j.issn.1672-1519.2004.03.32 |
| Key Words
Jinxin capsule;endothelial cell;LDL;SOD;MDA;CHD |
| Author Name | Affiliation | | JIANG Xi-yuan | Tianjin University of Traditional Chinese medicine, Tianjin, 300193, China | | FAN Ying-chang | Tianjin University of Traditional Chinese medicine, Tianjin, 300193, China | | ZHANG Hong-xia | 天津中医学院第二附属医院, 天津300150 |
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| Abstract
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| [Objective]To explore the mechanism of Jiuxin capsule in protecting endothelial cell and preventing or treating the coronary heart disease(CHD)by observing the effect on the ability of anti-oxidation injury in endothelial cell.[Methods]Cell injury model was established by Low density lipoprotien(LDL)with endothelial cell culture technique,and drugs was added through two different methods-sterilized pure extract and serum containing Jiuxin capsule.The changes of superoxide dismutase(SOD)activity and the content of malondialdehyde(MDA)were analyzed.[Result]The activity of SOD was decreased significantly,while the content of MDA was increased markedly after being injured by LDL.Jiuxin capsule could significantly inhibit this changes compared with the injury groups.[Conclusion]Jinxin capsule can protect endothelial cell and enhance the ability of endothelial cell against oxidation injury. |
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