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| Effect of Weichangle on NOS activity and CGRP contents in rats with stress gastric ulcer |
| Hits 2426 Download times 2052 Received:April 05, 2004 |
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| DOI
10.11656/j.issn.1672-1519.2004.03.35 |
| Key Words
Weichangle;Gastric ulcer;NOS;CGRP |
| Author Name | Affiliation | | PAN Hua-feng | The First Clinic Hospital of Guangzhou University of TCM, Guangzhou, 510405, China | | ZHAO Xia | The First Clinic Hospital of Guangzhou University of TCM, Guangzhou, 510405, China | | LIU You-zhang | The First Clinic Hospital of Guangzhou University of TCM, Guangzhou, 510405, China | | 王茵萍 | 江苏省人民医院, 南京210029 |
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| Abstract
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| [Objective]To investigate the mechanism of anti-ulcer function and protective effect to gastric mucosa cells of Weichangle(WCL).[Methods]Fourty-eight SD rats were divided randomly in 5 groups;normal group,model group,WCL high-dosage group,WCL middle-dosage group,WCL low-dosage group and Omeptazole group.The index of ulcer(UI)was measured by a vernier,the activity of nitric oxide(NOS)and contents of calcitonin gene-related peptide(CGRP)were de-tected by radioactive-immune-assay method.[Result]The UI in three kinds of dosage group of WCL and Omeptazole groups were significantly lower than those in model group(P<0.01).The activity of NOS and the contents of CGRP in three kinds of dosage group of WCL were obviously higher than those in the model group(P<0.01).[Conclusion]WCL can accelerate the healing of ulcer.The mechanisms maybe relate to its effect of promoting the activity of NOS and the increasing contents of CGRP,so as rotecting the gastric mucosa. |
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