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| Effect of Radix Aconiti matched with pinellia,fritillaria,trichosanthes,mapelopsis, bletallae on the cytochrome P450 content of liver in rats |
| Hits 1621 Download times 1797 Received:February 11, 2004 |
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| DOI
10.11656/j.issn.1672-1519.2004.04.24 |
| Key Words
cytochrome P450;contents of b5;eighteen imcompatible pairs |
| Author Name | Affiliation | | XIAO Cheng-rong | Institute of Radiation Medicine, Academy of Military Medical Science, Beijing100850, China | | CHEN Peng | Institute of Radiation Medicine, Academy of Military Medical Science, Beijing100850, China | | WANG Yu-guang | Institute of Radiation Medicine, Academy of Military Medical Science, Beijing100850, China | | 谭洪玲 | Institute of Radiation Medicine, Academy of Military Medical Science, Beijing100850, China | | 温怀青 | 西藏军区总医院, 拉萨, 850000 | | 高月 | Institute of Radiation Medicine, Academy of Military Medical Science, Beijing100850, China |
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| Abstract
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| [Objective] To study the effect of aconite matched with pinellia,fritillaria,trichosanthes,mapelopsis,bletallae on the content of cytochrome P450 and b5.[Method] Rat liver microsomal cytochrome P450,b5 contents were quantitated by UV chromatography.[Result] Compared with single used group,P450,b5 contents were obeviously decreased in combinative used group(p<0.001～0.05).[Conclusion] The contents of P450,b5 changed when these herbs were used together,giving effect on drug metabolism. |
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