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| A model in rat of chronic congestive heart failure |
| Hits 1586 Download times 2570 Received:July 07, 2004 |
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| DOI
10.11656/j.issn.1672-1519.2004.04.27 |
| Key Words
chronic congestive heart failure;animal model;hemodynamics |
| Author Name | Affiliation | | ZHAO Ying-qiang | The Second Afflicated Hospital to Tianjin University of TCM, Tianjin300150, China | | SUN Lan-jun | The Second Afflicated Hospital to Tianjin University of TCM, Tianjin300150, China | | XU Qiang | The Second Afflicated Hospital to Tianjin University of TCM, Tianjin300150, China | | 李慧臻 | The Second Afflicated Hospital to Tianjin University of TCM, Tianjin300150, China | | 王保和 | The Second Afflicated Hospital to Tianjin University of TCM, Tianjin300150, China |
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| Abstract
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| [Objective] To explore the preparation of the model of chronic congestive heart failure(CCHF)in rat.[Methods] The CCHF models was made by applying abdominal artery constriction.Whether successful or not in model producing was determined by testing the hemodynamic indexes.[Result] The HR in model group ascended from381.00±52.36per minute to471.00±57.84per minute(p<0.05);LEVT shortened from(80.27±24.02)ms to(52.55±22.26)ms.Both SV and CO descended significantly(p<0.05).It showed that the cardiac function descended obviously in model group 3 weeks after operation,while that in the control group had not any changes.The comparisons of HR,LVET,CO and SV between groups showed significant differences(p<0.05).[Conclusion] The model is made successfully.At the same time,obvious clinical syndromes in the CCHF rats are observed.Significant changes in the cardiac muscles of the rats can be observed electromicroscopically. |
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