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| Influence of Jiuxin Capsule on releasion of NO and ET-1from injuried endothelial cell |
| Hits 1734 Download times 1545 Received:March 05, 2004 |
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| DOI
10.11656/j.issn.1672-1519.2004.04.28 |
| Key Words
Jiuxin Capsule;endothelial cell;ET-1;NO |
| Author Name | Affiliation | | LV Bing-qiang | Tianjin University of TCM, Tianjin300193, China | | JIANG Xi-juan | Tianjin University of TCM, Tianjin300193, China | | ZHAo Gui-feng | Tianjin University of TCM, Tianjin300193, China | | 范英昌 | Tianjin University of TCM, Tianjin300193, China |
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| Abstract
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| [Objective] To research the mechanism of Jiuxin Capsule in the prevention and treatment of CHD by observing the influence of Jiuxin capsule on the vasomotor cytokine expression from the injuried endothelial cell(EC)after hypoxia and LDL.[Methods] Model with cell injury by hypoxia and LDL was established.After administration of the sterilized pure extract of drugs and the Jiuxin capsule containing serum the expression of ET-1,TXB2,PGF1a and NO was analyzed with radio-immunochemistry and bio-chemistry respectively.[Result] The results showed that the relax cytokine expression of EC after hypoxia and LDL decreased,however,contract cytokine expression increased.Jiuxin Capsule could improve this unbalance state.[Conclusion] By protecting EC and maintaining normal vasomotor state,Jiuxin Capsule can effectively prevent the formation and progress of CHD. |
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