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| Effect of salvianolic acid B advanced adaptation on expression of protein kinase C-mRNA of the hypoxia and ambohypoxia impairing cardiac capillaries endothelial cell |
| Hits 1702 Download times 1879 Received:March 05, 2004 |
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| DOI
10.11656/j.issn.1672-1519.2004.04.29 |
| Key Words
salvianolic acid B advanced adaptation;cardiac capillaries endothelial cell(CMEC);protein kinase C-mRNA |
| Author Name | Affiliation | | GUO Li-ping | The First Afflicated Hospital to Tianjin University of TCM, Tianjin300193, China | | DU Rong | 天津中医学院, 天津, 300193 | | ZHANG Meng | 天津中医学院, 天津, 300193 | | 高秀梅 | 天津中医学院, 天津, 300193 | | 商洪才 | 天津中医学院, 天津, 300193 |
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| Abstract
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| [Objective] To approach the mechanism of salvianolic acid B in protecting cardiac capillaries endothelial cell(CMEC)against hypoxia.[Methods] Based on the protective mechanism of the advanced adaptation,the expression of protein kinase C-mRNA was observed with molecular biology method,and the protective mechanism of salvianolic acid B on cells was approached.[Result] The expression of C-mRNA was upregulated in salvianolic acid B treated group and better than that in surpassed hypoxia advanced adaptation group(HPC).[Conclusion] Salvianolic acid B advanced adaptation has a similar cellular protective effect as HPC.It can enhance the tolerance longer hypoxia and ambohypoxia.The mechanism may be produced by related to the expressions of the protein kinase C-mRNA. |
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