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| Effect of Tongjingning Granule on Central and Peripheral β-EP in Rats with PD |
| Hits 1344 Download times 1661 Received:August 08, 2004 |
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| DOI
10.11656/j.issn.1672-1519.2004.05.26 |
| Key Words
Tongjingning Granule;PD;β-EP |
| Author Name | Affiliation | | SONG Zhuo-min | Tianjin University of Taditional Chinese Medicine, Tianjin 300193, China | | QU Cai-qin | Tianjin University of Taditional Chinese Medicine, Tianjin 300193, China | | ZHANG Yuan | Tianjin University of Taditional Chinese Medicine, Tianjin 300193, China | | 哈孝贤 | Tianjin University of Taditional Chinese Medicine, Tianjin 300193, China | | 邢淑丽 | Tianjin University of Taditional Chinese Medicine, Tianjin 300193, China | | 罗美玉 | 天津中医学院第一附属医院, 天津, 300193 |
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| Abstract
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| [Objective] To study the mechanisms of Tongjingning(dysmenorrheal-treating)Granule in analgesic function and the changes of ovary hormone in the course of PD(primary dysmenorrheal. [Methods] Rats were divided into three group randomly:control group treated with Aspirin(western medicine),model group with oxytocin and normal control group.The incidence rate of writhe reaction over the period of30min and60min was observed and the serum E2,P and the content of β-EP in hypothalamus,pituitary,ovary,uterus and plasma were detected by radioimmuassay(RIA). [Results] The incidence rate of writhe reaction in Tongjingning treated group is lower significantly than that of model group.Nega-tive correlation was found between E2 and β-EP.Positive correlation,however,was obtained between p and β-EP(P<0.01).The contents of β-EP in hypothalamus,pituitary,ovary,uterus and plasma in Tongjingning group were higher than that of model group and Aspirin group(P<0.01). [Conclusion] Tongjingning has a function of restraining convulsion and alleviating contraction of uterus muscle,can relieve convulsion and has analgesic effect.Ovary hormone is related to the pathologic occurring of PD.Tonjingning has a central and peripheral analgesic functions and can adjust the content of β-EP possibly by regulating ovary hormone. |
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