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| Reduction of bioavailability of glycyrrhizin from Shaoyao-Gancao-Tang by co-administered synthetic drugs and ways of minimizing it(PartⅡ) Effects of co-administered synthetic drugs on the bioavailability of glycyrrhizin from Shaoyao-Gancao-Tang Shaoyao_Gancao_Tang |
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| DOI
10.11656/j.issn.1672-1519.2004.05.37 |
| Key Words
drug-drug interaction;Shaoyao-Gancao-Tang;antibacterial drugs;glycyrrhizin;pharmacokiˉnetics;intestinal bacteria |
| Author Name | Affiliation | | HE Ju-xiu | Division of Kampo-pharmaceutics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan | | Tadoto Tani | Division of Kampo-pharmaceutics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan
21st Century COE Program, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan |
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| Abstract
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| In part I,we reported that the repetitive administration of Shaoyao-Gancao-Tang(SGT)increased the bioavailability of glycyrrhizin(GL)in SGT.In clinic,SGT is sometimes used together with some synthetic drugs.In this partⅡ,the influences of co-administered synthetic drugs on the pharmacokinetic fate of GL from SGT were investigated.The results showed that the co-administration of either a histamine2-receptor antagonist(cimetidine)or an anticholinergic drug(scopolamine butyl bromide,SBB)did not clearly influence the bioavail-ability of GL in SGT.However,the co-administration of a triple therapy OAM consisting of a proton pump in-hibitor(omeprazole,OPZ)and two antibacterial drugs(amoxicillin,AMPC,and metronidazole,MET)markedly reduced the plasma GA concentration.The reduction of plasma GA by OAM was shown to be due to the an-tibacterial drugs AMPC-MET,not the proton pump inhibitor OPZ.The mechanism of the reduction by AM-PC-MET involved the severe decrease of the GL-metabolizing activity of intestinal bacteria by AMPC-MET.These results suggest that it is not appropriate to simultaneously administer AMPC-MET with SGT. |
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