|
| Selection of Gene Expression Profile of Alzheimer’s Disease by cDNA Microarray |
| Hits 1539 Download times 2021 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2004.06.05 |
| Key Words
AD;SAM;gene expression profile;cDNA microarray |
| Author Name | Affiliation | | FAN Xiao-nong | The First Affiliated Hospital to Tianjin University of TCM, Tianjin 300193, China | | WEN Ting-yi | The First Affiliated Hospital to Tianjin University of TCM, Tianjin 300193, China | | DU Yuan-hao | The First Affiliated Hospital to Tianjin University of TCM, Tianjin 300193, China | | 韩景献 | The First Affiliated Hospital to Tianjin University of TCM, Tianjin 300193, China | | 李平 | The First Affiliated Hospital to Tianjin University of TCM, Tianjin 300193, China | | 王舒 | The First Affiliated Hospital to Tianjin University of TCM, Tianjin 300193, China | | 刘庆忠 | The First Affiliated Hospital to Tianjin University of TCM, Tianjin 300193, China | | 石学敏 | The First Affiliated Hospital to Tianjin University of TCM, Tianjin 300193, China |
|
| Abstract
|
| [Objective] To select the abnormal expression genes of Alzheimer’s Disease (AD) in Senescence Accelerated Mouse (SAM) and discuss their role in the pathogenesis of AD.[Methods] Using 15400 mouse cDNA microarray the abnormal expression genes in AD were screened.[Results] Two hundred and forty two genes related to dementia were selected, 234 genes related to senile were selected. One hundred and ten genes were selected in both groups considered to be related to both senile and dementia. Most the selected genes were down-regulated,the number of them were almost two-fold than that of up-regulated. The gene function of 22 in 110 were known. The down-regulated genes were mostly related to the pathological functions in releasing of synaptic vesicle, signal transduction, cell skeleton, energy metabolism, etc. On the other hand, the up-regulated genes were mainly involved in the pathologic functions of cell cycle, ion channel, protein synthesis, inflammatory reaction, and so on.[Conclusion]"Gene expression profile of AD" may find some rules in many clues in researches of AD and provide some evidences to reduce the blindness in the late study. |
|
|
|
|
|
|
|
