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| Experimental Research on Effects of Jiedu Quyu on Tumor Angiogenesis |
| Hits 1530 Download times 2014 Received:October 18, 2004 |
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| DOI
10.11656/j.issn.1672-1519.2004.06.10 |
| Key Words
Chinese herb;tumor;angiogenesis;cell apoptosis;Jiedu Quyu method |
| Author Name | Affiliation | | JIA Ying-jie | The Affiliated First Hospital to Tianjin University of TCM, Tianjin 300193, China | | TIAN Fei | The Affiliated First Hospital to Tianjin University of TCM, Tianjin 300193, China | | CHEN Jun | The Affiliated First Hospital to Tianjin University of TCM, Tianjin 300193, China | | 贾彦焘 | The Affiliated First Hospital to Tianjin University of TCM, Tianjin 300193, China | | 孙一予 | The Affiliated First Hospital to Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To demonstrate whether Jiedu Quyu (relieve toxicity and remove blood stasis) can inhibit, regulate angiogenesis gene expression, inhibit the growth and metastasis of tumor.[Methods] 1)The chicken embryo chronic membrane (CAM)was used. The inhibitory effect was observed and compared with that of hydrocortisone 48 hours later. 2)Using rabbits with tumor induced by corneal transplanation the inhibitory effect of Jiedu Quyu on angiogenesis was observed in tumor-loaded mice. [Results] Jiedu Quyu could significantly decrease, even dispear, the angiogenesis in CAM or rabbits. The inhibitory rate in tumor-loaded mice was 49.6%.It could lower the vascular density and accelerate the apoptosis of vascular endothelial cells in tumor.[Conclusion] Complex Jiedu Quyu medicine in TCM can inhibit the growth and angiogenesis of tumor in CAM, rabbits with tumor of corneal transplantation and mice loaded with tumor, suggesting Jiedu Quyu method can inhibit the growth of tumor through the inhibition of angionenesis. |
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