|
| Protective Effect of Classic Prescription Sinisan on Liver Injury and the Mechanism Study |
| Hits 1380 Download times 2377 Received:October 22, 2004 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2004.06.26 |
| Key Words
classic prescription;Sinisan;liver injury;lithocholic acid |
| Author Name | Affiliation | | ZHANG Guo-jun | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | WANG Dong-qiang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | SHI Li-pin | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 阚湘苓 | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 马东明 | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
|
| Abstract
|
| [Objective] To observe the protective effect of classic prescription Sinisan and the mechanism on liver injury. [Methods] Liver injury was induced by oral infusion of lithocholic acid with gastric tube. Level of serum ALT,AST,GSH,SOD and MDA was detected and the pathological observation of liver tissue was made. [Results] Sinisan could decrease the increased level of serum ALT,AST and MDA,and could increase the depressed level of serum SOD,GSH in rats with liver injury. The extent of pathological injury of liver tissue was alleviated markedly. Sinisan combined with rice water could decrease the level of AST,MDA apparently,while Sinisan decoction decreased level of ALT evidently. [Conclusion] Classic prescription Sinisan has certain protective effect on liver injury. |
|
|
|
|
|
|
|
