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| Reduction of Bioavailability of Glycyrrhizin Fim Shaoyao-Gancao-Tang by Co-administered Antibacterial Drugs and Ways of Minimizing it (Part Ⅲ) Restorative Effects of Repeated Administration of Shaoyao-Gancao-Tang |
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| DOI
10.11656/j.issn.1672-1519.2004.06.31 |
| Key Words
drug-drug interaction;Shaoyao-Gancao-Tang;antibacterial druns;glycyrrhizin;pharmacokinetics;intestinal bacteria |
| Author Name | Affiliation | | HE Ju-Xiu | Division of Kampo-pharmaceutics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan | | Tadato Tani | Division of Kampo-pharmaceutics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan
21 st Century COE Program, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan |
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| Abstract
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| (part Ⅲ):In part Ⅱ, we reported that the co-administration of antibacterial drugs AMPC-MET (amoxicillin, AMPC,and metronidazole, MET) significantly decreased the bioavailability of glycyrrhizin (GL) fim Shaoyao-Gancao-Tang (SGT),due to their decreasing effects on the Gl-metabolizing activity of intestinal bacteria. In this part Ⅲ, the lasting time period of the influences of AMPC-MET on the GL-metabolizing activity and an appropriate medication regiment to minimize the influences were investigated. The results showed that the decreasing effects of AMPC-MET on the GL-metabolizing activity lasted for approx 12 days. However, repetitive administration of SGT starting 1 day after the treatment with AMPC-MET for 4 days significantly accelerated the recovery of the reduced plasma 18 β-glycyrrhetic acid (GA) concentration and the GL-metabolizing activity of rat feces. The present results suggest that it may be clinically useful to administer SGT repetitively starting 1 or 2 days after the antibiotic treatment during combination therapy with SGT and antibiotics to accelerate the recovery of the reduced bioavailability of GL in SGT. |
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