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| The Relevance of EIF3 to Senescence and Acupuncture interference |
| Hits 1515 Download times 1604 Received:March 18, 2005 |
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| DOI
10.11656/j.issn.1672-1519.2005.02.06 |
| Key Words
Acupuncture;EIF3-P66;Senescence-associated gene;Silver staining;appoints |
| Author Name | Affiliation | | JIAN Chun-Yu | The first Teaching Hospital of Tianjin University of TCM, Tianjin 300193, China | | JING Xian-Han | The first Teaching Hospital of Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To explore the aging-associated genes of senescence accelerated mouse SAM and their relation to acupuncture. [Methods] The expression levels of cerebral genes of SAMP/10 with aging and acupuncture interference with aging were analyzed by applying DDRT-PCR technique. [Results] The expression level of a gene was observed to increase regularly with aging and revealed tendency to decrease after acupuncture points. Homology searching in the GenBank showed the fragment of the gene shares high homology with EIF3-P66 of mouse and human. [Conclusion] The accelerated aging of SAMP/10 is probably related to the abnormal over expression of EIF3-P66 and one of possible mechanism of acupuncture delaying the progress of aging is improve the abnormal synthesis of protein by down-regulating of its over expression. |
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