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| Experimental Study on Remedial Effect of Dahuanggansui Decoction in Synopsis of Golden Chamber on Hepatic Fibrosis in Mice |
| Hits 1567 Download times 1687 Received:January 10, 2005 |
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| DOI
10.11656/j.issn.1672-1519.2005.02.30 |
| Key Words
Dahuanggansui decoction;hepatic fibrosis;experimental study;Synopsis of Golden Chamber |
| Author Name | Affiliation | | LIU En-shun | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | MA Xiao-feng | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | FAN Ying-chang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the remedial effect and mechanism of Dahuanggansui Decoction on carbon tetrachlorate CCl4 -induced hepatic fibrosis in mice [Methods] Forty-two mice were randomly divided into normal group,model group and treatment group. Besides normal group,hepatic fibrosis was established in other two groups and the liver pathology,weight of spleen and body weight in each group were observed after 53 days. [Results] Density of depot fat cells per high power field in model group was higher obviously than that of the other two groups P<0.01. There was no significant difference between each group in spleen weight P>0.01. The body weight of mice in normal group was obviously higher than that in the other two groups P<0.01. [Conclusion] Dahuanggansui decoction has marked therapeutic effect on CCl4-induced hepatic fibrosis in mice,Its mechanism may be related to the inhibitory effect on the activation and transformation of depot fat cell and the decreased formation of fibroblast. |
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