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| Influence of Sini San on Expression of Bax Gene in Injuried Hepatic Cells |
| Hits 1775 Download times 1855 Received:January 11, 2005 |
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| DOI
10.11656/j.issn.1672-1519.2005.02.32 |
| Key Words
Sini San;liver injury;bax;apoptosis |
| Author Name | Affiliation | | WANG Dong-qiang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | ZHANG Guo-jun | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | SHI Li-pin | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| [Objective] To study the liver-protective effect through the observation on influence of Sini San on Bax-gene expression in injuried hepatic cells. [Methods] The hepatic injury was made by oral perfusion of lithocholic acid. The expression of Bax-gene of liver tissue was observed with immunohistochemistry. [Results] The positive expression rate of bax-gene of hepatic tissue in mice was increased by gavage of lithocholic acid and could be decreased by Sini San. [Conclusion] The liver protective effect of Sini San may be related to the decreasing effect of expression of bax-protein and liver cell apoptosis. |
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