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| Experimental Study on Effects of Panax Notoginseny Saponins on Hemodynamics in Rats with Myocardial Ischemia |
| Hits 1593 Download times 1789 Received:November 01, 2004 |
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| DOI
10.11656/j.issn.1672-1519.2005.02.33 |
| Key Words
Panax Notoginseny Saponins;acute myocardial ischemia (AMI);hemodynamics |
| Author Name | Affiliation | | LIU Jie | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | GAO Xiu-mei | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | WANG Yi | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 张伯礼 | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| [Objective] To explore the effect of Panax Notoginseny Saponins (PNS) on the hemodynamics in rats with acute myocardial ischemia (AMI). [Methods] (AMI) was established in rats by ligature of coronary artery. They were randomly divided into sham-operated group,model group,small-dose group of PNS and large-dose group of PNS. After treatment for 7 days,the hemodynamic indexes of left ventricle (LVSP,LVEDP,±dp/dt max) were measured. [Results] PNS could reduce the LVEDP and increase the ±dp/dt max. [Conclusion] PNS can improve the cardiac function,and large-doses of PNS have marked improveing effect on systolic and diastolic function of left ventricle. |
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