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| Effect of "Tiaoshenyiqi" Acupuncture on Excitatory Amino Acids in Brain of Rats with Multi-infarct-Dementia |
| Hits 2103 Download times 1620 Received:March 10, 2005 |
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| DOI
10.11656/j.issn.1672-1519.2005.03.27 |
| Key Words
"Tiaoshenyiqi" acupuncture rats with MID;EAAS |
| Author Name | Affiliation | | YUAN Hui-ru | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | LIU Cun-zhi | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | YU Jian-chun | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 马志国 | 河北省清河县第二人民医院, 清河, 054800 | | 王占国 | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | 韩景献 | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract
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| [[Objective] To observe the changes of the excitatory amino acid(EAAS) content in the brain of rats with multi-infarct-dementia(MID)treated with "tiaoshenyiqi"(regulating spirit and tonifying qi) acupuncture. [Methods] MID in rats was established by injecting emboli into the internal carotid artery. The rats were randomly divided into 3 groups:model group,acupuncture group and sham-acupoint group. Normal and sham-operated rats were used as control. The contents of EAAS(Glu,Gln,Asp,Asn) in cortex, hippocampus and striatum of the rats were detected after acupuncture and the intervention effect was analysed. [Results] The "tiaoshenyiqi" acupuncture can significantly decrease the content of Glu in hippocampus (P<0.05), of Gln in striatum (P<0.01), of Asp in cerebral cortex, hippocampus and striatum (P<0.05 or P<0.01), of Asn in cerebral cortex and striatum (P<0.05 or P<0.01). [Conclusion] The mechanism of the "tiaos henyiqi" acupuncture underlying improving demented status may be related to adjusting the EAAS levels in cortex, hippocampus and striatum. |
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