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| Effect of HHI-I on TNF-alpha Mediated Expression of Adhesion Molecules mRNA of Pulmonary Microvascular Endothelium in Rats |
| Hits 1482 Download times 1695 Received:April 12, 2005 |
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| DOI
10.11656/j.issn.1672-1519.2005.03.32 |
| Key Words
lung microvascular endothelial cell;cytokine;adhesion molecule;HHI-I |
| Author Name | Affiliation | | ZHANG Yan-Jun | Tianjin University of TCM, Tianjin 300193, China | | ZHAO Lian-gen | 天津市中西医结合急腹症研究所, 天津, 300100 | | WU Xiang-zhong | 天津市中西医结合急腹症研究所, 天津, 300100 |
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| Abstract
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| [Objective] To elucidate the mechanism underlying the effect of Huoxue Huayu(Activating blood circulation and remove stasis) herbal medicine on the recruitment of leukocytes in blood circulation. [Methods] The effect of HHI-I(Huoxue Huayu Injection No.I) on the expression of adhesion molecules mRNA induced by TNF-alpha was investigated in vitro with RT-PCR technique. [Results] In the cultured lung microvascular endothelial cells stimulated with TNF-alpha, the expression of adhesion molecules, such as E-selectin, P-selectin, ICAM-1 mRNA, was increased significantly. In contrast, the cells exposed to HHI-I simultan eously exhibited a marked lower expression of the TNF-alpha induced endothelial adhesion molecules. [Conclusion] HHI-I can inhibit the excessive expression of endothelial cell adhesion molecules. |
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