|
| Sex Differencien Osteopenia Induced by Adeninein Rats |
| Hits 1758 Download times 1269 Received:March 10, 2005 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2005.03.36 |
| Key Words
adenine;bone loss;sex difference;testosterone;17beta-HSD |
| Author Name | Affiliation | | TAKESHI OGIRIMA | Suzuka University of Medical Science, Kishioka, Suzuka 510-0293, Japan | | KAoRI TANO | Suzuka University of Medical Science, Kishioka, Suzuka 510-0293, Japan | | MASAYU KI KANEHARA | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | MING GAO | TheFirst Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193 | | XIAOMING WANG | Suzuka University of Medical Science, Kishioka, Suzuka 510-0293, Japan | | YI GUO | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | YANJUN ZHANG | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | LIPING GUO | The First Affiliated Hospital to Tianjin University of Traditional Chinese Medicine, Tianjin 300193 | | TORAO ISHID A | Suzuka University of Medical Science, Kishioka, Suzuka 510-0293, Japan |
|
| Abstract
|
| Adenine, which is common and essential to creatures, is widely used in clinical field. However, abundance of adenine is harmful to the living body. So far the male animals have been used for the research on adenine influence. In male rats, feeding of adenine-rich dietinduces renal failure. Because of very few studies of adenine influence to female animals,we investigated the influence of adenine treatment between male and female rats and discussed the sex difference on adenine treatment.Young male and female rats were administrated each adjusted adenine (6,50and 100mg/mL)for 8weeks (3times/week).In male rats,the renal failure was induced by 100mg/mL adenine treatment and renal dysfunction was induced by 50mg/mL adenine treatment.In female rats,however renal dysfunction was induced by 100mg/mL group only, and that was som ewhat different com pared to that in male rats. Serum testosterone level and BMD in male rats were decreased by adenine treatment with or without renal dysfunction. On the contrary, serum 17-beta estradiol level and BMD in female rats were not affected by adenine treatment at all regardless of renal dysfunction.As abovem entioned,this study could shed light on adenine effect on bone metabolism through sex hormone synthesis. A denine is commonly contained in clinical medicines and general food.Abundant ingestion of nucleic acid including adenine may affect the internal secretion function. |
|
|
|
|
|
|
|
