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Influence of Salvianolic Acid B and Tanshinone ⅡA on endothelial cells in rabbits with atherosclerosis
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DOI   10.11656/j.issn.1672-1519.2005.04.28
Key Words   Salvia miltiorrhiza;alvianolic acid B;tanshinone ⅡA;atherosclerosis;function of endothelial cells;target
Author NameAffiliation
ZHANG Yan-jun  
ZHANG Fa-yan  
FAN Ying-chang  
Abstract
    [Objective] To explore the influence of water-soluble active principle(salvianolic acid B) and fat-soluble active priciple(tanshinone ⅡA) on the functions of endothelial cells in rabbits with atherosclerosis.[Methods] Atherosclerosis was induced in rabbits by feeding cholesterol and oil.The influence of salvianolic acid B and tanshinone ⅡA on plasma TXB2,6-keto-PGF1α,ET was observed by radioimmunoassay.[Results] In the salvianolic acid B group,the content of TXB2,ET was reduced and the content of 6-keto-PGF1α was increased.But there was no significant difference between control group and tanshinone ⅡA group.[Conclusion] The mechanism of salvianolic acid B and tanshinone ⅡA in treating atherosclerosis is different.

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