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| Some Immunologic Characters in patients with Atopic dermatitis in Damp Abundance Due to Spleen Asthenia Syndrome |
| Hits 1445 Download times 1892 Received:March 20, 2005 |
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| DOI
10.11656/j.issn.1672-1519.2005.05.12 |
| Key Words
atopic dermatitis;IgE;IFN-γ;IL-4 |
| Author Name | Affiliation | | CHEN Bao-jiang | Tianjin University of TCM, Tianjin 300193, China | | ZHANG Yu-huan | 天津市长征医院, 天津, 300021 | | LIU Yu-fu | 天津市长征医院, 天津, 300021 | | 焦振山 | 天津市长征医院, 天津, 300021 |
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| Abstract
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| [Objective] To investigate the immune character in patients with atopic dermatitis in damp abundance due to splenic asthenia syndrome AD.[Methods] Sixty.one patients with atopic dermatitis were enrolled from out.patient clinic.Twenty healthy persons were as control.The level of serum total IgE was determined by ELISA The T cell subgroup of peripheral blood and Taccessory cell Th1/Th2 were determined by flow cytometry.The IFN.γ and IL.4 mRNA expression in eripheral blood mononuclear cells were determined by RT.PCR.[Result] The level of serum total IgE in patients with atopic dermatitis was higher than that in control group P<0.01.The percentage of CD3+T and CD4+T wase significantly higher than that in control group P<0.01 and P<0.05.But the percentage of CD8+T was remarkablely lower than that in control group P<0.05.The percentage of Th1 cell in the peripheral blood was significantly lower than that in control group P<0.01.The percentage of Th2 cell in the peripheral blood was significantly higher than that in control group P<0.01.The expression of IL.4 mRNA was significantly higher than that in control group P<0.01.[Conclusion] The high level of serum total IgE,the disorder of T cell function and the imbalance of Th1/Th2 were the immune character in patients with atopic dermatitis in damp abundance due to spleen asthenia syndrome. |
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