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| CInfluence of Acupuncture on Expression of bcl-2 and bax in Cerebral Cortex in Rats with Multi-infarct Dementia |
| Hits 1538 Download times 1478 Received:August 17, 2005 |
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| DOI
10.11656/j.issn.1672-1519.2005.05.21 |
| Key Words
acupuncture;multi-infarct dementia;bcl-2;bax |
| Author Name | Affiliation | | LIU Jian | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | ZHANG Zhan-jun | 北京中医药大学, 北京, 100029 | | FAN Xiao-nong | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | 李平 | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the influence of acupuncture on the expression of bax mRNA and protein of cerebral cortex in rats with multi.infarct dementia MID. [Methods] The MID in rats was established by infusion of autogeneic thrombus into carotid internal artery.The selected rats were randomly divided into four groups: model group,acupuncture group,non.acupoint group and sham operation group.In the acupuncture group Renzhong point,Neiguan point and Fengchi point were selected,while in the non.acupoint group two non.acupoint in the bilateral latus were used.The acupuncture was pricked once a day.The rats in the model and sham operation group were only caught and grasped at a same time interval and degree.Two weeks after treatment,the rats were killed by head.dislocation and the tissue of left brain was harvested.The expression of bcl.2,bax mRNA and protein was observed by in situ hybridization and immunohistochemistry. [Result] The expression of bcl.2,bax mRNA and protein in cerebral cortex in model group increased obviously.Further increase of bcl.2 mRNA and protein expression was found after acupuncture.But the expression of bax mRNA and protein decreased. [Conclusion] The acupuncture may promote the expression of bcl.2 mRNA and protein in cerebral cortex and inhibit the expression of bax mRNA and protein in cerebral cortex in rats with MID.This action may protect brain tissue and possesses acupoint specificity. |
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