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| Protective Effect of Huoxuehuayu Injection I Against Lethal Hypoxic Injury in Mice |
| Hits 1439 Download times 2021 Received:April 11, 2005 |
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| DOI
10.11656/j.issn.1672-1519.2005.05.31 |
| Key Words
hypoxia;brain edema;lung edema;survival time;mice |
| Author Name | Affiliation | | LIU Da-quan | Tianjin Institute of Acute Abdomen of Integrated Traditional Chinese and Western Medicine, Tianjin 300100, China | | ZHAO Lian-gen | Tianjin Institute of Acute Abdomen of Integrated Traditional Chinese and Western Medicine, Tianjin 300100, China | | CHEN Yu-ling | Tianjin Institute of Acute Abdomen of Integrated Traditional Chinese and Western Medicine, Tianjin 300100, China |
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| Abstract
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| [Objective] To observe the protective effect of Huoxuehuayu injection I HHI.I against lethal hypoxic injury in mice. [Methods] Forty Kunming mice were randomly divided into four groups.Ten mice were in each group with male and female distributed equally.During the experiment,0.9% saline control group,1.5% HHI.I low dosage group,3.0% HHI.I moderate dosage group and 6% HHI.I high dosage group,0.5 mL per mouse,were administrated respectively.One hour latter,the mice were put into a 5% hypoxic chamber and recorded their survival time in one hour period.After that,the water content of the brain and lung tissue samples was determined. [Result] Compared with the control group,6% HHI.I group could markedly decrease the water content in brain P<0.01.A tendency of decreasing of water content in lung was observed as well.But the difference in survival time wasn’t significant between groups.However,3% and 1.5% HHI.I group didn’t have the similar actions. [Conclusion] The 6% HHI.I has significant preventive effect against the brain edema formation induced with 5% hypoxia in mice. |
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