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| Effect of Xingnao Kaiqiao Acupuncture on Expression of ICAM-1 and P-selectin after Cerebral Ischemia and Reperfusion in Rat |
| Hits 1920 Download times 1729 Received:March 01, 2005 |
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| DOI
10.11656/j.issn.1672-1519.2005.06.11 |
| Key Words
Xingnao Kaiqiao acupuncture;cerebral ischemia and reperfusion;ICAM-1;P-selectin |
| Author Name | Affiliation | | LIU Yu-zhen | 464 Hospital of PLA, Tianjin 300381, China | | HAN Jing-xian | 天津中医学院第一附属医院, 天津, 300193 | | JIANG Wen | 天津中医学院, 天津, 300193 | | 李沛霖 | 天津中医学院, 天津, 300193 | | 夏天 | 天津中医学院, 天津, 300193 | | 于建春 | 天津中医学院第一附属医院, 天津, 300193 | | 李谈 | 天津中医学院第一附属医院, 天津, 300193 |
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| Abstract
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| [Objective] To explore the mechanism of Xiangnao kaiqiao (represhment and Inducing resuscitation) acupuncture against cerebral ischemia and reperfusion injury.[Methods] The cerebral ischemia and reperfusion injury was established by lineembolism of cerebral middle artery. The expression of ICAM-1 and P-selectin mRNA and protein in ischemic cerebral cortex and corpus striatum in rat was observed after 1 h of cerebral ischemia and 3,6,12,24 and 48 h of reperfusion by in situ hybridizatioin and immunohistochemistry.[Results] The mRNA expression of ICAM-1 and P-selectin was found at the capillary endothelial cells in the postischemia cerebral cortex 3 h after reperfusion and peaked at 12 h and 6～12 h respectively P<0.01 and increased continually during 48 reperfusion. Both expressions of mRNA and protein of ICAM and P-selectin in ischemia cerebral cortex were down-regulated considerably by Xiangnao Kaiqiao acupuncture P<0.01.[Conclusion] The Xingnao Kaiqiao acupuncture method may prevent and cure the cerebral ischemia and reperfusion injury by down-regulating the expression of mRNA and protein of ICAM-1 and P-selectin in ischemia cerebral cortex. |
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