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Influence of Tianma Xingnao Capsule on Cerebral Ischemia and Reperfusion Injury in Gerbil
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DOI   10.11656/j.issn.1672-1519.2005.06.28
Key Words   Tianma Xingnao capsule;gerbil;cerebral ischemia and reperfusion injury;electroencephalogram;water content;calciumion
Author NameAffiliation
YUN Yu Kunming Medical College, Kunming 650031, China 
WU Ying Kunming Medical College, Kunming 650031, China 
ZHANG Yan-bin Kunming Medical College, Kunming 650031, China 
郑金丹 云南省昭通制药有限公司, 昭通, 657000 
金燕 云南省人民医院, 昆明, 650001 
张家硕 Kunming Medical College, Kunming 650031, China 
沈志强 Kunming Medical College, Kunming 650031, China 
Abstract
    [Objective] To evaluate the neuro-protective effect of Tinma Xiangnao capsule(Gastrodia eleta refreshment capsule).[Methods] The cerebral ischemia and reperfusion injury was induced by 10-min bilateral occlusion of the common carotid artery and 5-day reperfusion in gerbils.[Results] The Tianma Xingnao capsule could obviously promote the recovery of the electric potential amplitude in electroencephalogram(EEG) after intragastric administration and decrease the water and calcium content in cortex in a dose-dependent manner.[Conclusion] The Tianma Xingnao capsule has a better protective effect against the cerebral ischemia and reperfusion injury in gerbil and the mechanism may closely correlated to the decreasing of the water and calcium content in the cortex.

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