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| Effect of TX0201 and Egb761 on APPmRNA,Aβ-positive Neuron and AChE in Rat with Alzheimer’s Disease Induced by Bilateral Injection of Aβ Corpus Amygdaloideum |
| Hits 1327 Download times 2050 Received:June 02, 2005 |
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| DOI
10.11656/j.issn.1672-1519.2006.01.04 |
| Key Words
Alzheimer’s disease;TX0201;β-amyloid protein;acetylcholine |
| Author Name | Affiliation | | YANG Ge | The Xiyuan Hospital of China Academy of TCM, Beijing 100091, China | | LI Mei-hua | The Worker’s Hospital, Kunming General Company of Iron and Steel, Kunming 650303, China | | JIN Hong-shu | Shanghai Institute of Gerontology with TCM, Shanghai 200032, China | | 郁志华 | Shanghai Institute of Gerontology with TCM, Shanghai 200032, China | | 张钦传 | Shanghai Institute of Gerontology with TCM, Shanghai 200032, China | | 林水淼 | Shanghai Institute of Gerontology with TCM, Shanghai 200032, China |
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| Abstract
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| [Objective] To research the mechanism of TX0201 Active position of Tiaoxin prescription(heart-regulating prescription)and EGb761(Danakang)on cholinergic system in rat with Alzheimer’s disease(AD).[Methods] AD was induced by Ab25-35 injected into the bilateral corpus amygdaloideum to observe the spatial learning and memory ability,AChE activity,and the expression of β-amyloid and β-amyloid precursor protein(APP)by RT-PCR and immunohistochemistry in the brain of the animal.[Results] In rats with AD the spatial learning and memory ability was damaged significantly,AChE activity decreased in its hippocampus.The expression of β-amyloid and APP mRNA increased in the cortex and hippocampus.TX0201 could improve the spatial learning and memory disturbance,decreased the expression of APP mRNA in hippocampus.[Conclusions] The TX0201 and EGb761 may obviously improve the learning and memory handicap of rats with AD by decreasing the expression of APP mRNA in hippocampus. |
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