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| Influence of Zinc Supplementation at Different Dosage on Learning and Memory Function and NOS Activity in Hippocampus of Rats |
| Hits 2107 Download times 2065 Received:September 14, 2005 |
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| DOI
10.11656/j.issn.1672-1519.2006.01.21 |
| Key Words
zinc(Zn);nitride oxide synthase(NOS);learning and memory function;hippocampus |
| Author Name | Affiliation | | WANG Xiu-yun | Tianjin University of TCM, Tianjin 300193, China | | LI Ji-sheng | The Institute of Military Preventive Medicine of Medical College of Armed-police, Tianjin 300162, China | | ZHU Hong | The Institute of Military Preventive Medicine of Medical College of Armed-police, Tianjin 300162, China | | 刘公望 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To explore the reasonable dosage of zinc supplementation for intervention with the sub-clinical patients and study the effect of zinc supplementation at different dosage on brain structure and function and their mechanism.[Methods] The change of learning and memory function and the activity of NOS(nitride oxide synthase)in different sub-unit of hippocampus in rats were observed by Y-lost-palace test and NADPH-d histochemistry.[Results] Zinc supplementation at low but adequate dosage(200 mg/kg zinc in forage)could improve the learning and memory function by increasing the activity of NOS in hippocampus construction and sub-regions of CA1 and CA3 and dentate gyrus of rats.Zinc supplementation with excessive dosage within a limit(400 mg/kg zinc in forage)hadn’t obvious curative effect.Excessive zinc supplementation beyond the limit(≥600 mg/kg zinc in forage)could impair the learning and memory ability and decrease the activity of NOS in hippocampus of rats.All of these might be one of the main mechanisms that excessive zinc supplementation beyond the limit could interfere with the learning and memory function.[Conclusion] Zinc supplementation at lower dosage can improve the learning and memory function of rats.Zinc supplementation at an excessive dosage can impair it.The changes of NOS activity in hippocampus may be one of the mechanisms of zinc affecting the learning and memory. |
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