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| Influence of Shanwei Prescription on P16 Protein in Atrophic Gastritis Patients in Precancer Period |
| Hits 1591 Download times 1749 Received:October 20, 2005 |
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| DOI
10.11656/j.issn.1672-1519.2006.01.24 |
| Key Words
Shanwei prescription;atrophic gastritis;precanserous lesion;P16 protein |
| Author Name | Affiliation | | ZHUO Yu-zhen | Tianjin University of TCM, Tianjin 300193, China | | YUAN Hong-mei | Zouping County Hospital of TCM in Shandong Province, Zouping 200256, China | | WANG Xue | Zouping County Hospital of TCM in Shandong Province, Zouping 200256, China | | 袁红霞 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the curative effect of Shanwei(improving the structure and function of stomach)on chronic atrophic gastritis(CAG)with gastric mucous membrane dysplsia(Dys)otr intestinal metaplasia(IM)and observe the expression of antioncogene protein P16 before and after treatment.[Methods] The selected patients were suffered from CAG with Dys or IM diagnosed with endoscopy and pathologic examination.Sixty patients were randomly divided into treatment group and control group.The patients of treatment group were administered with Shanwei prescription and patients of control group with heriacium tablets for six months.[Result] The total effective rate of treatment group and control group was individually 90.00% and 55.67%.There was obviously difference between the treatment group and control group(P<0.01).The treatment group had obvious higher effect than control group on improvement in the atrophy extent,intestinal metaplasia and gastric mucous membrane dysplasia(P<0.05).The antioncogene protein P16 expression of treatment group was obviously higher than that of control group(P<0.05).[Conclusion] Sanwei prescription has definitely curative effect on carcinoma of stomach with precancerous lesion and may reverse the pathologic change of gastric mucous membrane on a certain extent by increasing the expression of P16 protein. |
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