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| Influence of Jiuxin Capsule on PAI-1 mRNA Expression of Endotheliocyte Injured by Hypoxia in Human Umbilical Veins |
| Hits 1777 Download times 1493 Received:June 10, 2005 |
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| DOI
10.11656/j.issn.1672-1519.2006.01.29 |
| Key Words
Jiuxin capsule;endotheliocyte;PAI-1 mRNA |
| Author Name | Affiliation | | HUA Sheng-yu | Tianjin University of TCM, Tianjin 300193, China | | ZHANG Hong-xia | The Second Affiliated Hospital of Tianjin University of TCM, Tianjin 300150, China | | FAN Ying-chang | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To observe the protective effect of Jiuxin(treating heart disease)capsule on the endotheliocyte of human umbilical vein injured with hypoxia by inhibiting the PAI-1 mRNA expression.[Methods] In the endotheliocyte injured with hypoxia and LDL the expression of PAI-1 mRNA was determined in Jiuxin capsule contained serum with in situ hybridization.[Result] The expression of PAI-1 mRNA was obviously increased in hypoxia state and Jiuxin capsule can decrease the PAI-1 mRNA expression.[Conclusion] Jiuxin capsule has a good effect in protecting endotheliocyte injury by regulating blood coagulation and preventing the thrombosis secondary to the coronary atherosclerosis. |
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