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| Effects of Sleep Deprivation (SD) on Sub-clinical Condition and Its Correlative Mechanisms |
| Hits 1636 Download times 2200 Received:December 02, 2005 |
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| DOI
10.11656/j.issn.1672-1519.2006.02.09 |
| Key Words
sub-clinical state;sleep deprivation (SD);behavioral science;Brain cognition function;hippocampus formation;NOS;nNOS |
| Author Name | Affiliation | | WANG Xiu-yun | Tianjin University of TCM, Tianjin 300193, China | | LI Ji-sheng | Institute of Military Preventive Medicine, Medical College of Armed Police, Tianjin 300162, China | | LIU Gong-wang | Tianjin University of TCM, Tianjin 300193, China | | 陈爽白 | Tianjin University of TCM, Tianjin 300193, China | | 玉井秀明 | Tianjin University of TCM, Tianjin 300193, China | | 周震 | Tianjin University of TCM, Tianjin 300193, China | | 赵慧仁 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To explore the influence of sleep deprivation (SD) on sub-clinical condition and cerebral function and interpret the possible mechanism.[Methods] Based on the investigation of main symptom of sub-clinical condition in about one thousand persons, the SD model in rats was made and their behavior was researched to explore the effect of SD on the stress ability. Y-lost palace test was adopted to research the influence of SD on the ability of cognition of brain. The activity of NOS and the levels of protein expression of nNOS in hippocampus of rats were researched to explore the action and the mechanism of SD on the function of brain and body.[Results] In the group of students, the first symptom was sleep-disorder and then fatigue; In the group of farmers, however, the first symptom was fatigue and the second sleep-disorder, indicating the sleep-disorder played an important role in sub-clinical state. In the research of rats, it was found that after sleep deprivation, the behavior of rats became inhibited, the stress ability became lowered. SD could reduce the results of Y-lost palace test (P<0.05), reduce the levels of NOS and nNOS in hippocampus of rats (P<0.05) and result in the injury of the function of cognition of brain, such as learning and memory.[Conclusions] Sleep-disorder is the main symptom of the sub-clinical state. SD can make the function of brain lowed. It is indicated that SD plays an important role in the formation and development of sub-clinical state. Its mechanism may be related to the reducing of the levels of NOS and the protein expression of nNOS in hippocampus. |
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