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| Effect of Tanshinone ⅡA on Expression of MCP-1 and IL-1β in Injured Smooth Muscle Cell Induced by TNF-α |
| Hits 2709 Download times 1899 Received:February 18, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2006.03.05 |
| Key Words
tanshinone ⅡA;MCP-1;IL-1β;experimental research |
| Author Name | Affiliation | | ZHOU Gui-tong | Tianjin University of TCM, Tianjin 300193, China | | ZHAO Gui-feng | 天津市塘沽区杭州道医院 天津300451 | | FAN Ying-chang | Tianjin University of TCM, Tianjin 300193, China | | 范英昌 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To explore the influence of Tanshinone ⅡA on the expression of MCP-1 and IL-1β in the vascular smooth muscle cell. [Methods] Cultivate the aorta smooth muscle cell of rats and reproduce the TNF-α injured model. The expression of MCP-1 and IL-1β was determined by RT-PCR and radioimmunology assay and the effect of tanshinone ⅡA was observed. [Results] The transhinone ⅡA may inhibit MCP-1 and IL-1β overexpression of vascular smooth muscle cell injured by TNF-α. [Conclusions] Inhibiting MCP-1 and IL-1β overexpression in atheroclerosis process may be one of the mechanisms of transhinone IIA. |
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