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| Comparison of Models of Fatty Liver and Hyperlipidemia Between Mice and Rats |
| Hits 1589 Download times 10501 Received:January 02, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2006.03.06 |
| Key Words
comparison of experiment animal models;hyperlipidemia;fatty liver |
| Author Name | Affiliation | | WANG Wei | Tianjin University of TCM, Tianjin 300193, China | | JIANG Hai-tao | Tianjin University of TCM, Tianjin 300193, China | | LI Yu-hong | Tianjin University of TCM, Tianjin 300193, China | | 史红 | Tianjin University of TCM, Tianjin 300193, China | | 张远 | Tianjin University of TCM, Tianjin 300193, China | | 屈彩琴 | Tianjin University of TCM, Tianjin 300193, China | | 胡利民 | Tianjin University of TCM, Tianjin 300193, China | | 高秀梅 | Tianjin University of TCM, Tianjin 300193, China | | 张伯礼 | Tianjin University of TCM, Tianjin 300193, China |
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| Abstract
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| [Objective] To establish an ideal animal model in the research for treating and preventing fatty liver and hyperlipidemia. [Methods] The male Wistar rats, SD rats and Kunming mice were used differently and randomized into control group and model group. The model group was fed with high sugar and high fatty diet consisted of 10% grease, 1% cholesterol, 15% sugar, 74% common animal forage. The control group was fed with common animal forage. The index of serum TC, TG, AST, ALT; liver TC, TG, ratio of liver weigh/body weigh and liver pathology was observed. [Results] Serum TG, TC, AST, ALT; liver TC, TG, ratio of liver weigh/body weigh of the SD model group rats were higher than that of the control group. The difference was not found in other two animal model groups and their control group. Hepatocyte steatosis in liver was observed in the SD rat model group. [Conclusions] The male SD rat was the most optimum animal for reproducing an ideal disease model for studying the prevention and treatment of fatty liver and hyperlipidemia through feeding high sugar and high fatty diet for 4 weeks. |
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