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| Effects of Jiawei Wuzi Yanzong Recipe on Space Learning and Memory Result of Dysmnesia Mice |
| Hits 1367 Download times 1702 Received:January 03, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2006.03.27 |
| Key Words
Jiawei Wuzi Yanzong Recipe;Alzheimer’s disease;dysmnesic? |
| Author Name | Affiliation | | CHU Song-ling | Institute of Integrated Traditional and Western Medicine, First Hospital of Peking University, Beijing 100034, China | | WANG Xue-mei | Institute of Integrated Traditional and Western Medicine, First Hospital of Peking University, Beijing 100034, China | | LIU Geng-xin | Institute of Integrated Traditional and Western Medicine, First Hospital of Peking University, Beijing 100034, China |
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| Abstract
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| [Objective] To investigate the effects and mechanisms of Jiawei Wuzi Yanzong Recipe and its components on improving of learning and dysmnesia in the mice with learning and memory disorders induced by scopolamine. [Methods] Morris water maze with the video recorder and computer systems (MVRC) were used to assess the behavior performances of the mice by detecting the search strategy in place navigation experiment, then detect and compute the times of the mice cross the target region in space probe experiment. [Results] Significant differences were observed between model group and Jiawei Wuzi Yanzong Recipe and its components treated groups (P<0.01). Compared with model group, the percentage of the linear and appulsive search strategy was promoted in place navigation experiment (P<0.01). The times of the mice cross the target region in space probe experiment were markedly higher in Jiawei Wuzi Yanzong Recipe and its components treated groups(P<0.05). [Conclusions] Jiawei Wuzi Yanzong Recipe and its components can improve the behavior performances of the model mice with learning and memory disorders induced by scopolamine in Morris water maze. Jiawei Wuzi Yanzong Recipe and its components possesses a certain preventive effects on learning and memory function in model mice with impairment of central cholinergic system. The polysaccharides of the recipe seems more efficient. |
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