|
| Improvement and Evaluation on Model of Multiple Infarction Dementia |
| Hits 1310 Download times 1547 Received:February 12, 2006 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2006.03.28 |
| Key Words
multiple infarction dementia(MID);cortex;hippocampus;Morris Water Maze (MWM) |
| Author Name | Affiliation | | WANG Tong | Tianjin University of TCM, Tianjin 300193, China | | YU Jian-chun | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | JIANG Wen | Tianjin University of TCM, Tianjin 300193, China | | 刘存志 | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China | | 韩景献 | The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China |
|
| Abstract
|
| [Objective] To improve and evaluate the model of multiple infarction dementia (MID) induced by thrombus injection. [Methods] MID was established by inverse injection of thrombus into external carotid artery to observe the pathologic changes in hippocampus and cortex region of brain and the ability of spatial learning and memory with Morris Water Maze(MWM). [Results] The pathologic examination showed multiple infarcted focuses in MID group in brain region. The amount of neural cell decreased in cortex,severe cell lost and cell arrangement disorder in hippocampus region were observed. Behavior test showed that in MID group some severe disturbance existed in the ability of learning acquisition and memory retaining, and the course of learning and memory is delayed. [Conclusions] MID established by thrombus injection was feasible and reproducible. |
|
|
|
|
|
|
|
