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| Effect of Tiankui Gengnian Soft Capsule on Antioxidant Action in Old Rats |
| Hits 1797 Download times 1935 Received:February 20, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2006.03.29 |
| Key Words
TGSC;MDA;SOD;GSH-Px;mitochondria;ROS |
| Author Name | Affiliation | | LEI Fang | Xi’an Medical Ccollege, Communication University, Xi’an 710061, China | | WANG Zhen-lin | Xi’an Medical Ccollege, Communication University, Xi’an 710061, China | | WEI Xia-zhen | 西安交大天奎医药生物公司 西安710061 | | 申屠平平 | Xi’an Medical Ccollege, Communication University, Xi’an 710061, China |
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| Abstract
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| [Objective] To observe the effect of Tiankui Gengnian Soft Capsule(menstruation-climacteric soft capsule, TGSC) on the antioxidant action in old rats and provide the experimental basis for investigating the mechanisms of anti-aging effect of TGSC. [Methods] After feeding rats with TGSC for 45 days, the influence on the activity of SOD, MDA in serum and brain, MAO in brain and activity of GSH-Px in blood was observed. At the same time, the ROS and activity of MDA in liver mitochondria were also explored. Finally, the lipofuscin accumulation in cerebral cortex was examined by light microscope. [Results] TGSC could obviously improve the level of some indexes in blood, brain and mitochondria, decreasing the lipofuscin accumulation in cerebral cortex. [Conclusions] TGSC has antioxidant effect. This may explain the mechanism of its anti-aging effects of it. |
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