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| Multi-objective Optimization Research of The Ratio of Danshen and Sanchi with ED-NM-MO Trigeminy Method |
| Hits 2103 Download times 1745 Received:January 02, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2006.03.31 |
| Key Words
ED-NM-MO Method;the ratio of danshen and sanchi;baseline geometric proportion increasing and decreasing design;nonlinear fitting;multi-objective optimization;RBF NN;Evolutionary Program;the Pareto Archived Evolution Strategy(PAES);Pareto optimal solution |
| Author Name | Affiliation | | WANG Rui | Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, China | | SHANG Hong-cai | Tianjin University of TCM, Tianjin 300193, China | | WANG Yong-yan | Chinese Academy of TCM, Beijing 100700, China | | 张伯礼 | Tianjin University of TCM, Tianjin 300193, China | | 高秀梅 | Tianjin University of TCM, Tianjin 300193, China | | 赵宜军 | Chinese Academy of TCM, Beijing 100700, China |
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| Abstract
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| [Objective] To optimize the dosage and ratio of danshen(Rasix Salviae Milt orrgizae) and sanchi(Radix Notoginseng) by processing the experimental data with ED-NM-MO Method. [Methods] Aimed at pharmacodynamics indexes, the pharmacodynamic data of the ratio of danshen and sanchi based on baseline geometric proportion increasing and decreasing design were nonlinearity fitted and multi-objective optimized. [Results] Pareto optimal ratio for six and seven pharmacodynamics indexes was individually obtained. [Conclusions] ED-NM-MO Method is suited for the researching of the characters of Chinese medicine, and it can be used for the optimization of dosage and ratio of herb or component compound. |
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