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| Effect of the TCM on γ-GCS Expression of Rats with Several Type of Chronic Obstructive Pulmonary Diseases and Pathology of Respiratory Tract |
| Hits 1608 Download times 1446 Received:April 20, 2006 |
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| DOI
10.11656/j.issn.1672-1519.2006.04.24 |
| Key Words
Chronic Obstructive Pulmonary Disease(COPD);γ-GCS;the traditional Chinese medicine |
| Author Name | Affiliation | | ZHANG Wei | Tianjin University, Tianjin 300072, China | | Li Gang | Tianjin University, Tianjin 300072, China | | ZHANG Xin-yue | Shandong University of TCM, Jinan 250014, China | | 邵雨萌 | Shandong University of TCM, Jinan 250014, China |
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| Abstract
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| [Objective] To explore the therapeutic mechanism of TCM in treating chronic obstructive pulmonary disease(COPD)through observing the level of glutamylcysteine synthetase(γ-GCS)and the pathologic changes of the airway tract in COPD rats.[Methods] COPD in rats was induced by modified fumigation and lipopolysaccharicle(LPS)dropping into trachea.The pathologic changes of the small airway tract in rats were observed microscopically and the changes of tracheal cilium of the the COPD rats electron microscopically.The γ-GCS expression level was determined immunohistochemistry.[Results] Each prescription could alleviate the infiltration of the inflammation cells and the block of secretion in bronchioles of lung and the terminal bronchiole tube cavity.It could also restore the cilium from adhesion,lodging and shedding,thus improve the high reactivity and remodeling of the airway tract.Compared with the normal group,a high expression of γ-GCS was found in bronchus,alveolus epithelium,smooth muscles cells and inflammatory cells in each model group(P<0.01)Obvious convalescence was found after treatment(P<0.05).It was indicated that the jadescreen powder could repair the COPD airway and alleviate the inflammation.[Conclusions] The traditional Chinese medicine can rectify the disbalance of oxidation and anti-oxidation in COPD rats,alleviate the inflammatory reaction and can repair the COPD airway and can treat each types of COPD efficiently. |
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